Anti-arthritic Effect of 1'-acetoxychavicol Acetate in Complete Freunds Adjuvant-induced Arthritis in Rats

1'-Acetoxychavicol acetate (ACA) is a phenylpropanoid present in Alpinia galanga (L) Willd syn. Languas galanga. The objective of this study was to isolate 1'-Acetoxychavicol acetate (ACA) from acetone extract of Alpinia galanga (AEAG) and evaluate anti-arthritic activity of 1'-Acetoxychavicol acetate (ACA) and acetone extract of Alpinia galanga (AEAG) on complete Freund’s Adjuvant-induced arthritis in rats. Radiographic and histopathological observations were evaluated. AEAG (400 mg/kg) and ACA (10 and 20 mg/kg) suppressed the paw swelling, increased the paw withdrawal latency, and reduced the paw thickness in arthritic rats. Radiological and histopathological characteristics in ACA (20 mg/kg) treated rats were comparable with that of diclofenac treated rats. The present study indicates that ACA and AEAG showed significant antiarthritic activity.